Wednesday, March 18, 2020

Next Generation & the Future of Erectile Dysfunction Treatments

Erectile dysfunction also synonymously known as ED affects nearly half of men between the ages of 40 and 70 to some extent. Vascular diseases interrelated with aging, hyperlipidemia, smoking, diabetes as well as hypertension, are often linked to erectile dysfunction. Furthermore, injury to cavernous nerves in the penile region “comprises an appreciable number of ED cases.” ⁶ Other causes of erectile dysfunction include but are not limited to endocrine disorders, as well as fibrosis of the penile tissue and corporal smooth muscle.¹¹ Overall both vasculogenic and neurogenic erectile dysfunctions are linked to the loss of normal cellular function or cell death (apoptosis).

Oral medications such as phosphodiesterase-5 inhibitors (PDE5is), have clear benefits, and are typically first-line treatments in regards to erectile dysfunction, however their actions are short lived.⁶ Lifestyle changes and injections are also typical first line treatment options for the management of complex cases of erectile dysfunction. Most recently scientists and physicians have been focusing on new next generation novel therapy options as a way to restore natural sexual function; one such treatment option includes Stem Cell based Bioactive Factor Therapy.

Stem-cell-based therapies focus on the management of erectile dysfunction “through the protection of the threatened host cells via immunomodulatory effects, and the provision of trophic factors or gene delivery.”¹¹ In recent years, a number of research studies related to the progress of stem cell-based erectile dysfunction therapy have been published. This is yielding strong evidence supporting the concept that stem-cell-based bio-active therapy is potentially the next generation therapeutic approach for erectile dysfunction. Furthermore, research studies conducted have taken into account a large spectrum of stem cells, including mesenchymal stem cells, tissue as well as muscle -derived stem cells for further investigation in regards to vascular, neural, endothelial or smooth muscle regeneration in animal models for erectile dysfunction.

What are Mesenchymal Stem Cells?

Stem cells are cells that differentiate into smooth muscle cells, neurons, endothelial cells and other types of varying cells. Stem cells by definition have the capability of self-renewal, meaning that they can make copies of themselves for an indefinite period, and differentiate into a variety of phenotypes.¹^,² Stem cells are defined by their “capacity for both self-renewal and directed differentiation. Thus, they represent great promise for regenerative medicine.” Stem cells can be categorized as either embryonic stem cells (ESCs) or adult stem cells (ASCs). Embryonic stem cells (ESCs) are acknowledged as an example of pluripotent cells.⁶ While multipotent stem cells include mesenchymal stem cells (MSCs) as they “are capable of self-renewal, and they can differentiate into any cell type within their germ layer”.⁴

Stem cells have diverse properties that make them potentially viable for utilization in various disease treatments. In particular, adult MSCs are “multipotent cells that undergo self-renewal and differentiation” as well as express specific surface markers.¹³ MSCs can be derived from different sources within the body, including adipose tissue, bone marrow as well as the umbilical cord membrane. ¹³, ¹² Historically, MSCs were founded by a researcher named Friedenstein through the conduction of studies on the bone marrow although MSCs can be isolated from other adult tissues including adipose tissue. ⁷^,⁵ The word “Stem Cells” more correctly known as “Mesenchymal Stem Cells” (MSCs) were termed MSCs secondary to their innate ability to duplicate while maintaining the attribute of multi-potential lineage.

MSCs “contain growth factors, signaling lipids, mRNAs, and regulatory miRNAs, which are involved in tissue repair as paracrine mediators.” ¹³^,¹⁴ Research studies have also suggested that exosomes released by MSCs may aid erectile dysfunction linked to diabetes through anti-fibrotic mechanisms, preventing cell death as well as increasing smooth and endothelial muscle content. ¹⁵^,¹⁸

What are Bioactive Factors and EVs?

MSCs are able to secrete soluble “Bioactive Factors” which aid in modulating the immune system, improve the standard rate of healing injured tissues and reduce inflammation. Stem Cell Bioactive Factors consist of nanoparticles which are released from the membranes of Mesenchymal Stem Cells (MSCs). These nanoparticles contain over “200 Growth factors, Cytokines and Nucleic Acids which support healthy cell-to-cell communication and are responsible for the therapeutic effects observed in regenerative medicine.”

EVs or extracellular vesicles are membrane-packed vesicles that are secreted by MSCs. ⁹ EVs have been demonstrated to perform a critical role in cell-to-cell communication and important processes such as immune responses, homeostasis maintenance, and more. ⁸^,⁹

Microvesicles, an important EV, may “change functional target cells by delivering intracellular proteins”; for example, MVs released from endothelial cells can promote the regeneration through transfer of growth factors and their activators. ¹² MSC-derived EVs (MSC-EVs) based stem cell therapies are easier to manage and safer “due to their inability to directly form tumors.” ¹⁰

Mesenchymal Stem Cell’s Bioactive Factors

Bioactive Factors demonstrate numerous advantages when compared to Mesenchymal Stem Cells:

Bioactive Factors do not contain DNA as they have no cells therefore there is no risk of a malignant transformation.
Bioactive Factors contain nano-particles which can travel systemically without the risks of clumping.
Bioactive Factors have the ability to cross the Blood Brain Barrier (BBB) and are able to exert their neurotrophic effects.
MSCs can be perceived as “foreign” by our own immune system (both innate and adaptive), however Bioactive Factors are able to evade immune response.

Essentially Bioactive Factors exert far more therapeutic effects than Mesenchymal Stem Cells could.

Therapeutic Effects of Stem Cell Bioactive Factors

Growth factors, Cytokines and Nucleic Acids within Stem Cell Bioactive Factors are catalysts for regeneration as they contribute to tissue and organ repair, alter inflammation, aid in neural communication, improve mitochondrial viability and participate in the alteration of aging cells. Overall Bioactive Factors derived from Stem Cells aid the body in repairing damaged tissues and injuries.

Stem Cell Bioactive Factors have been utilized by Medical Professionals for a number varying aspects including but not limited to soft tissue repair, and restoring sexual wellness. In regards to men’s sexual health Stem Cell Therapy rejuvenates, repairs and regenerates damaged penile tissues, aiding in the restoration of erectile function which may contribute to the elimination the need for long term reliance on drugs.

Some Examples of Bioactive Factors

VEGF (Vascular Endothelial Growth Factors): Aids in the creation of new blood vessels, and in the generation of muscles through bypassing blocked vessels.
PDGF-BB (Platelet Derived Growth Factor Sub Unit B): Stimulates the healing of soft as well as hard tissues.
TGF B3 (Transforming Growth Factor B3): Aids in the conversion of inflammatory T cells into anti-inflammatory Regulatory T cells.
GDF 15 (Growth Differentiation 15): Regulates inflammation and aids in cell repair as well as growth.

How Boston Medical Group Sources Bioactive Factors

Boston Medical Group utilizes Bioactive Factors produced from an FDA-registered Tissue Banks which follow strict GMP guidelines as well as implement and maintain FDA regulations. The Tissue Bank sources from the highest quality donors and harvests from the healthiest part of the placenta in order to produce viable MSCs from which secreted Bioactive Factors are collected at the highest point potency. Upon the completion of manufacturing, each batch is sent for third party testing regarding microbiology and other safety protocols.

Clinic Trials Regarding Stem Cell Therapies and Erectile Dysfunction

Stem Cell Therapy can utilize varying types of stem cells including MSCs. Stem cells may also treat erectile dysfunction by supporting penile tissue through paracrine or hormone effects such as the “release of repair cytokines triggering endogenous mechanisms of regeneration separate from the trans-differentiation of stem cells into different cell types.” ¹⁴ Furthermore MSCs do not necessarily need to be engrafted within tissue to create a functional and structural response to the therapy administered.

Phase one studies in humans have shown “results in terms of tolerability, safety, and efficacy of use of stem cell transplant for the treatment of erectile dysfunction.” ¹⁸ Recent studies have also suggested that the combination Shock Wave Therapy and Stem Cell Therapy may decrease cell destruction within the penile corpora region as well as promote the growth of new blood vessels. ¹⁹

A literature review from ScienceDirect regarding the efficacy of Stem Cell Therapy revealed that five previously completed human clinical trials did show promise for Stem Cell Therapy as “being a restorative treatment option for erectile dysfunction”.²⁰ The five studies included in the literature review utilized different types of stem cells, including various mesenchymal stem cells (MSCs). A total of 61 patients were included in the give studies, with mean ages of men being between 50 and 70 years. The literature review found that the majority of the five studies suggested improvement in erectile function and vascular flow in the penile region due to stem cell therapy without the report of serious adverse events occurring during the follow-up period. ²⁰

Stem Cell Therapy may be a paradigm shift in the growing number of treatment options available for erectile dysfunction. Stem Cell Therapy has been recognized for its therapeutic properties in regards to aiding in treatment for various conditions including erectile dysfunction. Boston NextGen Therapy embraces the latest in advanced technologies to help men restore erectile function without the use of drugs or the long term reliance on drugs. Boston Medical Group utilizes treatment protocols which are personalized to the individual’s conditions and may combine regimens such as shockwave therapy called RejuvaPulse Therapy, BostonPRP Injections and Stem-Cell Bioactive Factors. Thanks to a vast amount continuing research and development, Boston Medical Group physicians have culminated the most efficacious treatment protocols and continue to be the market leader in the field Erectile Dysfunction.

Boston Medical Group’s Optimum Regenerative Solution

Boston Medical Group utilizes the latest in next generation revolutionary treatment options for Erectile Dysfunction while upholding to GMP guidelines, and the utmost standards or requirements regarding the utilization of FDA registered tissue procurement organizations for Stem Cell Therapy. Boston Medical Group utilizes Bioactive Factors and EVs secreted from the membranes of placental-derived MSCs (Mesenchymal Stem Cells) which possess more than 200 growth factors as well as other immune factors which can render considerable therapeutic benefits, especially in the field of Regenerative Medicine***.

References

Figure 1. https://www.wjgnet.com/1948-0210/full/v11/i9/618.htm#F1

Article source here: Next Generation & the Future of Erectile Dysfunction Treatments

Monday, March 9, 2020

Viagra Not Working? Here’s What You Can Do

Viagra Not Working? This Guide Can Help You

Once categorized as a psychological disorder, erectile dysfunction is now regarded as a physiological ailment through numerous coherent studies. According to Harvard Health Publishing, impotence is more common than expected, with a prevalence of up to 22% in American men, mostly in the older age groups.¹ However, younger men are also at risk, considering the fact that the leading causes of ED are chronic diseases, capable of interrupting regular blood flow and nerve functionality, with examples including; diabetes, hypertension, multiple sclerosis, as well as hormonal imbalance.¹

Although very difficult for many men to accept and admit to this condition, we are lucky to live in an age of pharmaceutical furtherance, providing us with medication that works for treating ED. Sildenafil, sold as the brand name Viagra among other oral medication in pill form were the first to rush to rescue men dealing with impotence. However, similar to several other medications, there is no guarantee that Viagra will work, so the question we are asking today is what should we do when Viagra doesn’t work?

Possible Health Reasons Why Your Viagra is Not Working

A healthy erection is dependent on an uninterrupted blood flow to the penis, through the penile cavernous arteries, to fill the corpora cavernosa, therefore, causing the stiffening of the penile shaft. An erection is initiated with sensory and mental stimulation, with an emphasis on proper neural functioning. We cannot ignore performance anxiety and fatigue; however, physical irregularities are the primary causes of ED, therefore, medications such as Viagra are prescribed to push past the abnormal blood circulation and increase blood flow to the cavernous arteries, working as a vasodilator. Besides Viagra’s prolonged onset of action, the crisis many users face revolves around the ineffectual aspect of sildenafil and its recommendations against use by men with severe cardiovascular ailments.⁴ Viagra just doesn’t work for some men.

Low-Testosterone Levels

Testosterone is the key hormone produced by the Leydig cells of the testicles and is responsible for the normal growth and development of male organs and for maintenance of other sexual characteristics. During their late twenties, men begin to encounter the decline and imbalance of hormones, specifically testosterone. Depletion of testosterone, which is referred to as andropause is accompanied by several symptoms³:

Increased body fat and loss of muscle mass
Depleted bone mass and energy levels
Hair loss
Disturbed sleep patterns and mood swings
Erectile dysfunction.

Such imbalance has a significant role in sexual desire and performance. Although, testosterone is an essential component of a healthy sex life, it is not a requirement for normal and consistent erections. Viagra cannot replace or maintain testosterone levels, meaning Viagra (and other Sildenafil brand names) will not work as a replacement for the natural urge or desire for sex. Patients should seek testosterone replacement or hormonal therapy instead.³

STDs

Another topic of emphasis is around the use of ED medication and contracting an STD. ED medication does not work as a protective barrier against STDs and everyone should practice safe sex regardless. Meanwhile, certain STDs can possibly lead to erectile dysfunction, making ED medication less effective. An example of the mentioned scenario is an individual who contracted Chlamydia, and did not seek proper medical attention, allowing the bacteria to grow and infect the prostate gland, leading to prostatitis. It is very useful to know ED medication cannot be used and will not work for protection against STDs, and everyone should always practice safe sex

Diabetes

ED is very prominent in men with diabetes. The incidence rate of ED increases with age from 5% in men age 20 to 75% in men over age 65.⁴ The primary cause of impotence in diabetic men is due to the decrease in the blood flow and nerve damage in the penile area as a consequence of diabetes. Many diabetic patients have successfully been treated with Viagra since 1998, followed by Cialis, Levitra, and Stendra ever since. However, diabetic patients might also fail to enjoy the therapeutic advantages of such oral medication after building resistance or from the very first pill. Around 50 percent of men with Type 1 diabetes and 60 percent of Type 2 diabetic patients have reported improved erectile conditions.⁴

Meanwhile, a huge portion of diabetic men are left untreated or unresponsive to Viagra, primarily due to the damaged blood vessels and nerves caused by diabetes. The absorption and systematic flow of the medicine after ingestion is also altered in diabetic patients, making it more difficult for the drug’s action mechanism to work its biochemical effect. Many diabetic patients will report little or no difference in erection habits even after using Viagra and similar products.⁴

The Root of Your ED is Psychological

As mentioned before, ED is also impacted by psychological factors. Anxiety and depression is very popular among men who report erectile dysfunction or similar problems. Psychological pressure can influence sexual stimulation, causing discomfort or lack of response to stimuli.⁵ Performance anxiety and stress may be responsible for the lack of effect that Viagra has in many men. It is equally important to be comfortable mentally as well as physically during sexual activities for Sildenafil-based medications to work.

Using a Low Dose or Using it Incorrectly

It is very important to realize that the correct method of use and dosage is the key to Viagra working as desired.⁷ This translates to taking Viagra or Levitra at least an hour before engaging in sexual activity for it to be working properly. The drug must also be taken on an empty stomach preferably or avoiding a heavy meal prior to taking the medication, in order to maximize uptake.

Alcohol intake must be reduced to a minimum, since alcohol decreases the blood flow and circulation, making Viagra less effective. Sufficient stimulation is also another recommended approach to working the most out of your ED medication.⁶

Typically, doctors prefer to start the patient with the lowest dose, since daily administration can lead to improved blood flow to the penile area on a regular basis. Also, this method of administration may guide the doctors to determining the appropriate amount needed to treat ED, without the risk of overdosing. Similarly, a very low dosage might also not have the desired impact on the erections, causing many users to seek other treatment options that actually work, without trying to adjust the prescribed dose of the current medication with the help of a medical professional.

Giving Up Early On It

It is logical and recommended to try a certain medication a few times before moving on to the next if it’s not working at first. The chances of error and incorrect use might make it difficult to see results after first use, so, the user must be patient and allow several attempts.⁶ A correct explanation for lack of results after the initial use could be the inappropriate dose, taking Viagra on a full stomach, or expecting it to work immediately after ingestion.

What ED Treatment Options Are Out There?

As mentioned, we do live in a world driven by pharmaceutical advancements, and there is no reason to give up hope finding treatment for such a common disorder. Multiple treatment options are available with relatively higher or lower success rate to Viagra and similar products, but, it is important to realize some individuals might be more responsive to certain treatment options compared to others, due to certain underlying conditions, physiological differences, or severity of their ED.⁷

Other Options For Treating ED When Viagra Won’t Work

ICP

Considered a very effective but often under-utilized treatment for Erectile Dysfunction, ICP involves an injection of a combination of FDA-approved vasodilators into the spongy tissue of the penis, using an auto-applicator. This combination causes an expansion of the penile arteries and penile tissues, resulting in increased blood flow to the penis. An erection typically develops within minutes. The erection feels perfectly natural and normal; however, it will not subside after ejaculation until the effect of the medicine wears off. In rare cases side-effects of ICP include penile bruising, pain or tenderness, scarring, and a prolonged erection (known as a priapism). Boston Medical Group physicians have developed a unique approach to this method that has been effective for thousands of patients. Because it is applied locally and is non-systemic, it is often recommended for men with diabetes, heart conditions, high blood pressure or other illnesses. In the last 15 years ICP has re-emerged as a treatment option for men who do not respond to well-known oral medications for ED. Many men prefer to use ICP over other methods given its record of safety, quality, and highly predicable results.

Hormonal Replacement Therapy

Some men experience a condition called andropause, similar to menopause in women, which can be caused by low testosterone. Symptoms can include, but are not limited to, feelings of sluggishness, fatigue, poor sleeping habits, weight gain, low sex drive, or erectile dysfunction. For the appropriate candidate, hormonal replacement therapy can be valuable in reversing these symptoms and even improve libido (sexual drive).

Blood tests are required for the purpose of diagnosis, monitoring the treatment effectiveness, as well as any other adverse side-effects.

Sublingual Tablets

For men who can otherwise tolerate the side-effects of Oral Medications but want a more potent and faster acting solution. These tablets have the same contraindications and side effects as standard Oral Medications but due to faster absorption they have a faster onset of response.

PRP

Platelets are components of blood that contains a number of growth factors which have the ability to promote the repair and healing of damaged or injured tissue throughout the body.

Platelet-Rich Plasma is prepared by taking a small sample of blood and subjecting it to centrifugation (spinning the blood sample at a high rate of speed), which separates red blood cells and white blood cells from the remaining plasma. The remaining plasma is “packed” with platelets that remain behind, hence the term Platelet-Rich Plasma (PRP).

Once PRP is collected and injected into the “injured” tissue, PRP releases growth factors which then trigger the natural healing process.

Penile Surgery

Penile surgery and such procedures are often termed as last resort, and are advised to be considered only after all other treatment options are exhausted without success.

Penile Prosthesis

In this surgical procedure, semi-rigid rods or inflatable prostheses are inserted in the erectile tissue, after removal of the mentioned tissue. The placement of an implant requires permanent injury and adjusting of the erectile tissue of the penis, and this makes the treatment irreversible, without the guarantee of success.

Arterial and Venous Surgeries

Approximately 2% to 5% of patients are candidates for vascular reconstructive surgery, which includes arterial bypass and venous ligation. Risks include those related to other major surgical procedures. Boston Medical Group physicians do not perform these surgeries.

Non-Invasive Treatment

With the introduction of ED treatments, some had to find a way to be treated without the use of medication or surgery. Non-invasive treatment options are available to those who prefer long-term results.

Rejuvapulse Therapy

RejuvaPulse is a completely non-invasive therapy that
uses pulsed sound waves to deliver energy to targeted penile tissue which activates the body’s own healing and regenerative properties. This results in healthy, new blood vessels, increased blood flow, and stronger, firmer erectile performance. RejuvaPulse is generically referred to as Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT) or simply Shockwave Therapy.

RejuvaPulse therapy breaks up micro-plaque; repairs aged blood vessels, and stimulate the growth of new vessels, a process called neovascularization. After a series of six to twelve treatments of about 20 minutes each, RejuvaPulse therapy results in penile rehabilitation, regeneration, and rejuvenation.

Vacuum Suction Device

A VSD is a battery or manually-operated cylindrical pump which fully encloses the penis. When activated, it creates a vacuum by sucking air out of the sealed chamber, which draws blood to the penis. A firm rubber ring is placed around the base of the penis to trap the blood in the erectile chamber, which keeps the penis firm. Disadvantages can include incomplete erections, discomfort, and the time required for operation, but VSDs are often valuable when used along with other treatments, like ICP.

Psychological Help And Other Wellness Treatments

Sex Therapy

Sex therapy is often the treatment of choice for patients with psychological Erectile Dysfunction. It demands the cooperation of the sexual partner, multiple sessions, and an experienced sex therapist for the best results.

Despite the psychological and physiological factors affecting impotence, it is very important to try different treatment options and find the right fit with the help of a doctor. Many factors such as diet, weight, incorrect use, low dosage, Low-T, diabetes, and giving up early will make it slightly difficult to experience the best of the available treatment options.² It is vital to follow the correct instruction for use, in order to maximize the effect of medication.

Diabetes and Low testosterone both affect the body in ways which might interfere with the action mechanism of certain medical products. Sexual desire, which is regulated by hormonal balance and testosterone, is an important factor which pills like Viagra and Cialis cannot regulate. Be more attentive to underlying conditions which make it difficult for Viagra and similar products to work.² As mentioned before, if Viagra doesn’t work, there are plenty of other treatment options available. Contact Boston Medical Group to learn more about the multiple treatment options provided for erectile dysfunction, premature ejaculation, and low testosterone levels.

Sources:

Article source here: Viagra Not Working? Here’s What You Can Do

Tuesday, February 18, 2020

Blood Testing For Sexual Health

As human beings, we each are basically a body of cells, composed mostly of bones and blood encased in a large organ, our skin.

Blood, of course, delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away. Cells are mainly red blood cells, white blood cells and platelets.

Boston Medical Group offers blood tests. This testing is a part of an overall methodology to ascertain the best treatment options for each patient.

The most abundant cells in vertebrate blood are red blood cells. These contain hemoglobin, an iron-containing protein, which facilitates oxygen transport by reversibly binding to this respiratory gas and greatly increasing its solubility in blood. In contrast, carbon dioxide is mostly transported extracellular as bicarbonate ion transported in plasma. And the way we discover our overall health is most often tied to what’s in and what’s not in our blood.

While blood tests may be very common for patients getting normal or annual checkups, there are certain, specific tests one’s doctor might want to order to evaluate your overall health. These special tests could be needed to ascertain if symptoms or even just general issues like you age, weight, blood pressure or personal habits could be contributing to risks. Even more importantly, they can signal alerts or warning signs of the need for immediate medical attention.

Usually, blood tests don’t require any unusual preparations. But in some instances, you might need to not eat any food for up to 12 hours before the blood draw. Your doctor or assistant usually advises you how to prepare for certain or general blood tests.

A Laboratory draws the blood in order to analyze it. Either whole blood is used to count blood cells, or the blood cells are separated from the fluid that contains them, called plasma or serum.

The plasma fluid is used to measure different substances in the blood. The results can help detect early stages in health problems. This is when treatments or lifestyle changes can work best.

It should be noted that doctors cannot diagnose all diseases and medical problems just with blood tests. There might be other factors utilized to confirm a diagnosis. Symptoms, medical history, vital signs, such as blood pressure, breathing, pulse, and temperature, and results from other tests and procedures administered come into play.

Blood – Your Body’s Information Highway

Your blood can reveal a lot about your overall health. Lab work merely a part of a puzzle piece and can be used to determine what’s going on.

“Blood tests help diagnose, treat, and manage heart disease. Your blood provides many hidden clues about your heart health. For example, high levels of “bad” cholesterol in your blood can be a sign that you’re at increased risk of having a heart attack. And other substances in your blood can help your doctor determine if you have heart failure or face a risk of developing plaque in your arteries (atherosclerosis). It’s important to remember that one blood test doesn’t always determine your risk of heart disease. The most important risk factors for heart disease are smoking, high blood pressure, high cholesterol, and diabetes.”*

Testing, Testing, One Two… E.D.

“It’s not easy for men to talk about problems in the bedroom. An inability to have sex with penetration can result in a stigma around being unable to perform. Worse, it might mean having difficulties in fathering a child. But it can also be a sign of a dangerous underlying health condition. A blood test can reveal issues beyond problems attaining or sustaining an erection. Read through this article to learn why blood tests are important. A blood test is a useful diagnostic tool for all sorts of conditions. Erectile dysfunction (ED) can be a sign of heart disease, diabetes mellitus, or low testosterone (low T), among other things. All of these conditions can be serious but are treatable and should be addressed. A blood test can determine whether you have a high sugar (glucose) level, high cholesterol, or low testosterone. In men with heart disease, the vessels that send blood to the penis can get clogged, just as other blood vessels can. Sometimes ED can be a marker of vascular dysfunction and atherosclerosis, which results in reduced blood flow in your arteries. Complications of diabetes can also result in a lack of blood blow to the penis. In fact, ED can be an early sign of diabetes in men under 46 years old. Heart disease and diabetes can cause ED, and this can be associated with low T. Low T also can be a sign of health conditions such as HIV or opioid abuse. Either way, low T can result in reduced sex drive, depression, and weight gain.”**

The Boston Medical Group Centers & Your General Health

Having treated hundreds of thousands of men worldwide, Boston Medical Group physicians understand both the physical and psychological effects of sexual dysfunction. With that in mind, all of Boston Medical Group medical centers are built with individual waiting rooms to create comfortable and private patient experience.

All visits are by appointment only to limit the number of patients in the office at any given time. Further, The Boston Method® is designed so that all testing and treatment is completed right there in the office without the need for any off-site travel.

* https://www.leehealth.org/our-services/cardiology/blood-tests

** https://www.healthline.com/health/erectile-dysfunction/blood-tests

Article source here: Blood Testing For Sexual Health

Friday, February 7, 2020

Valentine’s Day. Wherefore Art Thou, Cupid?

Valentine’s Day would not be complete without Cupid, the most recognized symbol of love. Nope, we are not talking about one of Santa’s reindeer. We are speaking of Cupid, the God of Love. It is said that if Cupid shoots his arrow of love and hits you, that you will fall helplessly and madly in love with the next person you meet.

In Roman mythology, Cupid is the son of Venus, the goddess of love. In Greek mythology, he was known as Eros and was the son of Aphrodite.

According to Roman mythology, Cupid fell madly in love with Psyche despite his mother’s jealousy over Psyche’s beauty. While he married her, he also told her never to look at him. He visited her only at night. Her sisters convinced her to look at Cupid despite his warning. So, she lit a lamp one night so she could see him. Cupid then left her.

Psyche wandered aimlessly for a time, searching in vain for Cupid. She happened upon the temple of Venus. Venus, looking to destroy her, gave Psyche a series of perilous tasks, each one more difficult and previous than preceding one. Her final task was to deliver a little box to the underworld and get some of the beauty of Proserpine. She was warned not to open the box. But again, curiosity overcame her and she opened the box. There was nothing in the box but deadly slumber.

Cupid, who really loved Psyche all the while, came upon her lifeless body. He forgave Psyche and swept the deadly slumber back into the box. The gods then made Psyche a goddess. – source: holidayinsights.com

Cupid and Psyche is a story originally from Metamorphoses (also called The Golden Ass), written in the 2nd century AD by Lucius Apuleius Madaurensis (or Platonicus). The tale concerns the overcoming of obstacles to the love between Psyche (“Soul” or “Breath of Life”) and Cupid (Latin Cupido, “Desire”) and their ultimate union in a sacred marriage. Although the only extended narrative from antiquity is that of Apuleius from 2nd century AD, Eros and Psyche appear in Greek art as early as the 4th century BC.

Since the rediscovery of Apuleius’s novel in the Renaissance, the reception of Cupid and Psyche in the classical tradition has been extensive. The story has been retold in poetry, drama, and opera, and depicted widely in painting, sculpture, and even wallpaper.^[5] Though Psyche is usually referred to in Roman mythology by her Greek name, her Roman name through direct translation is Anima. – source: Wikipedia

Boston Medical Group Extends a Happy Valentine’s Day to All

Sources for text and art:

http://www.holidayinsights.com/valentine/cupid.htm

https://en.wikipedia.org/wiki/Cupid

https://en.wikipedia.org/wiki/Cupid_and_Psyche

What would cupid do without his arrow?

Article source here: Valentine’s Day. Wherefore Art Thou, Cupid?

Wednesday, February 5, 2020

Overcoming Intimacy Issues While Dealing with Prostate Problems

Old-fashioned beliefs suggested erectile dysfunction to be psychological in origin. While anxiety and stress are factors that can cause ED, scientific advances now provide proof that in a majority of cases, it is traced back to physical conditions which interrupt nerve functioning and restrict blood flow.¹ Diabetes, arthrosclerosis, cardiovascular conditions, as well as some types of prostate disease and their treatments are responsible for most cases of ED.³ This article will focus on how prostate diseases have impacted erections and sexual activity.

Erection is a matter of synchronous body function, which fills the penile tissue with blood, allowing it to swell and stand erect. This process requires an orchestrated mechanism, lead by blood vessels, endocrine system, and the nervous system, and obviously, any interference can affect the quality of an erection.² Nitric oxide promotes vasodilatation while neurotransmitters such as norepinephrine and acetylcholine increase the production of chemicals such as guanosine monophosphate, prostaglandins, and polypeptides which initiate the erection process by shifting chemical gradients in the muscles and capillaries of the corpora cavernosa, which runs along the shaft, causing inflation and swelling of the penis.¹

It is important to understand how conditions such as prostate disease can interrupt the above mentioned process, leading to abnormal erections or inconsistency in the erectile functioning. It is also helpful to realize limited erections for one or two nights does not mean you have ED.

Prostate Cancer

Sudden and frequent erectile problems can be a symptom associated with prostate cancer, so a prostate-specific antigen, PSA test, accompanied by a rectal exam is performed to assess the situation.

Prostate surgery to remove tumors is often associated with the high risk of nerve damage or cardiovascular complications due to the site specificity of such surgeries. Many choose radical prostatectomy, which only 25% to 80% of men can regain their abilities to maintain any erection.¹ Patient’s medical background and the surgeon’s experience are often taken into consideration when evaluating the chances to regain sexual abilities after a surgical procedure.⁴ Rehabilitation takes up to eighteen months, and that alone takes away from the sexual functioning of men in many cases. Radiation therapy very often harms erectile mechanisms, as both the radiation beam and the radiation-emitting seeds implanted in the prostate can severe the nerve and the muscle cells.²

Hormone therapy is another treatment option which men with prostate cancer opt-in for, but such medication such as goserelin and leuprolide may also translate to ED symptoms, since interference in the endocrine system can greatly impact the erectile mechanism.⁶

Benign Prostate Hyperplasia

BPH is a non-cancerous enlargement of the prostate, which can greatly impact erectile and ejaculatory function. An enlarged prostate, does not lead to ED, rather some of the treatments used for this condition can lead to ED. Finasteride is an example of an anti-testosterone which is used to treat BPH, can cause reduction in libido, and in turn switch off the erectile engine in men. Transurethral resection, a surgical procedure used in the reduction of the prostate gland has also failed to skip ED as one of its side-effects.⁶

Prostatis

Simply known as the inflammation of the prostate gland, prostitis can be acute, or chronic, which is either caused by an infectious agent or not respectively, can trigger ED in many men. Aside from pain, frequent urination, and discharge from the penis, this condition can directly cause ED. It can also be accompanied by painful ejaculation and lack of sexual pleasure for men. The infection can clear in several weeks if treated, but the chronic form can be a permanent problem for some men.⁷

However, there is no need to panic. Every failed attempt to maintain an erection is not ED. When the male genitals don’t get hard enough, or it loses the rigidity and softens soon after an erection, there might be some speculations about ED. It might take longer to get an erection, and in other occasions, the erection might not be as firm or last as long. With such conditions witnessed regularly, it would be time to contact your doctor, and figure out a way to stop this condition in its tracks. With all the new medical discoveries and pharmaceutical advances, a right solution for you might be easier to access than you might imagine.

Diagnosis Methods*

In order to confirm a case of erectile dysfunction, a visit to your primary care physician, urologist or ED specialist would be required. Below is a table from Harvard Health Publishing which summarizes the procedure followed by doctors for each possible cause of erectile dysfunction:

Possible cause of erectile dysfunction	What the doctor does
Vascular (circulatory system)	Takes your blood pressure and listens to your heart. Checks pulse in groin and feet. Checks your abdomen for aortic aneurysm.
Neurological (nervous system)	Tests reflexes of your knees and ankles, as well as anus. Checks for sensation in your legs and feet.
Hormonal (endocrine system)	Assesses testicular size and breast development. Checks your thyroid gland.
Local (reproductive system)	Examines your penis for Peyronie’s disease. Checks your prostate.
Psychological (stress, anxiety, emotional)	Assesses the history of the problem, especially whether it started suddenly and if nocturnal erections are affected.

*Table from Harvard Medical School’s Health Publishing: Sex and Prostate (2009)¹

Doctors who specialize in ED treatments often use advanced diagnostic equipment to measure: blood flow, nerve sensitivity, and hormonal levels.

Treatment Method

Despite the fact that there is no definite cure for ED, we can remain hopeful on not giving up sexual activities due to such conditions that limit our sexual abilities. We live in an era where we are offered multiple treatment options to overcome such limitations and to regain the sexual abilities and cravings. Men with prostate diseases might be at most risk for developing ED, right next to cardiovascular disease patients, inactive individuals, and individuals who do not pay attention to their diet and mental health.⁷ Overcoming erectile dysfunction while dealing with prostate cancer is not an easy job but we can’t sit around and hope for a miracle to happen. The first step for a healthier sex life post-diagnosis of a prostate disease is the will and determination to make it happen. The next step is contacting specialists and evaluating the treatment options available to you. You can also help the recovery and treatment by remaining active, consuming a balanced diet, and taking the treatment seriously. Below is a list of all the modern and most popular treatment options available:

Therapy	Duration of Action Mechanism	Effectiveness Duration	Pros	Cons
IC Injections (ICP, Fx)	10-15 Minutes	30-75 Minutes	Highly Effective (98%), Few side effects	Training required; Injection might be uncomfortable for some men; may cause pain or priapism
Sound Wave Therapy (Rejuvapulse)	While In Use	Long-term	Non-invasive, Effectiveness varies (up to 85%), Non-pharmaceutical	Takes longer to see results.
Sildenafil (Viagra)	30-60 Minutes	3-5 Hours	Oral form, Effective (70%),	Not suitable for men with cardiovascular diseases or on blood pressure medication and nitrates. Side-effects.
Vardenafil (Levitra)	15-30 Minutes	3-5 Hours	Oral form, Effective (70%)	Not suitable for men with cardiovascular diseases or on blood pressure medication and nitrates. Side-effects.
Tadalafil (Cialis)	30-45 Minutes	2-3 Days	Oral form, Effective (70%)	Not suitable for men with cardiovascular diseases or on blood pressure medication and nitrates. Side-effects.
Alprostadil Pellets	Immediate	While In Use	Effective for some (80%)	Requires training; may cause burn; awkward and might cause bruising
Penile Bands	Immediate	While In Use	Needs adjustment. Cheap	Tricky to use
Stem cell Technology	On-going sessions	Long-term	Next-Gen; Permanent results; Personalized	Expensive

There are some misconceptions about this condition which gives an inaccurate image to many individuals dealing with erectile dysfunction.

MYTH: Erectile dysfunction only affects the elderly.

FACT: After the age of 45, almost 1 out of 2 men experience some sort of ED. It is true that ED occurs more prevalently as men age, however, men can retain their erectile functioning well unto their 80s, but it is medication and age-related conditions that exaggerates the occurrence of ED.³

MYTH: Men must accept and live with erectile dysfunction.

FACT: Effective and modern treatment options are readily available. Contact an ED specialist.⁴

MYTH: ED is a psychological disease.

FACT: Studies show only 10%-30% of ED cases are linked with psychogenic factors. Vascular disorders, abnormalities, nerve damage, endocrinologic disorders and prostate problems build up the remaining 70%-90% of ED cases.³

MYTH: Erectile dysfunction is not common.

FACT: A case study found 52% of Americans have some degree of ED between the ages of 40 to 70 years, and approximately 35% had moderate to severe ED.³

Sources:

Article source here: Overcoming Intimacy Issues While Dealing with Prostate Problems

Thursday, January 30, 2020

The Link between Diabetes, Erectile Dysfunction and Intimacy Issues

Did you know that the root causes of Erectile Dysfunction (ED) can be linked to pre-existing health conditions? There are several prevalent conditions that can increase the likelihood of developing Erectile Dysfunction. One such pre-existing condition that increases the likelihood of developing Erectile Dysfunction includes Diabetes. Research studies suggest that the prevalence of developing Erectile dysfunction for “men with diabetes ranges from 35%–75% versus 26% in general population.” ⁽¹⁾ This reveals that men with Diabetes have a significantly higher risk for developing Erectile Dysfunction then the general population due to complications resulting from Diabetes.

Overall men who are Diabetic have approximately a “threefold higher probability to develop Erectile Dysfunction compared with non-diabetics” ⁽²⁾. This suggests that the chances of developing impotence are much higher if an individual has a pre-existing condition such as Diabetes. According to the American Diabetes Association “the onset of Erectile Dysfunction occurs 10–15 years earlier in men with diabetes than it does in sex-matched counterparts without diabetes.^{” (1)}. Research also conducted by the Boston University Medical Centre, has found that “about half of men who are diagnosed with type 2 diabetes will develop ED within five to 10 years of their diagnosis.” ⁽³⁾

Not only is Erectile Dysfunction more common in men who have been diagnosed with Diabetes, research studies suggest that Erectile Dysfunction in Diabetic men “has been shown to be more severe and associated with a poorer quality of life” ^{(5, 6)}. Furthermore, studies have shown that men who have ED are “less responsive to medical treatment compared with ED in non-diabetic men” ^{(5, 6)}.

So what’s causing Erectile Dysfunction stemmed from Diabetes?

Erectile Dysfunction can stem from several complications associated with Diabetes. One such complication includes poor long-term blood sugar control which results in damage to “damage small blood vessels and nerves” increasing the likelihood to develop Erectile Dysfunction. ⁽³⁾ Another complication includes “low nitric oxide levels which are commonly found in individuals with Diabetes.” ⁽¹⁾ When a man is aroused, a chemical called nitric oxide is released into the bloodstream. This nitric oxide signals the muscles and the arteries in the penis to relax, allowing for more blood to flow into the penis, giving an erection. When a man’s blood sugar levels are too high, there is less nitric oxide produced resulting in less blood flowing into the penis therefore causing the inability to achieve or maintain an erection. Gh levels of nitric oxide act as local neurotransmitters therefore facilitating the maximization of blood flow as well as penile engorgement. “Loss of erection occurs when nitric oxide–induced vasodilation ceases”, or with low nitric oxide synthase levels. ⁽¹⁾ Individuals with Diabetes have a higher chance of developing Erectile Dysfunction due to the interference of nitric oxide synthesis as it prevents “intracavernosal blood pressure from rising to a level sufficient to impede emissary vein outflow, leading to an inability to acquire or sustain rigid erection.” ⁽¹⁾

Another complication of Diabetes which can facilitate impotence includes the reduction of Norepinephrine- and acetylcholine-positive fibers two substances which attach to skeletal muscle fibers in the penile tissue region. These two substances are shown “to be reduced in people with diabetes” resulting in the “loss for muscle relaxation that is essential for achieving an erection.” ⁽¹⁾ The reduction in these two fiber substances arises from damage to the nerves as well as blood vessels caused by long term imbalances in blood sugar level. Additionally, the use of medications frequently assumed to be administered by diabetic patients, such as “antihypertensive drugs (β-blockers, thiazide diuretics, and spironolactone), psychotropic drugs (antidepressants), and certain fibrates, have all been associated with an additive deleterious effect on diabetic Erectile Dysfunction.” ⁽⁵⁾ Overall Erectile Dysfunction linked to Diabetes is multi-factorial in nature and there can be several underlying causes attributing to the condition so a global approach in regards to treatment may be required.

Let’s Talk about Prevention, Supplements and Treatment Options

The first step in preventing or resolving Erectile Dysfunction includes addressing the root cause of the problem. Initially, preventive measures or steps towards multi-factorial intervention can help to reduce the risk of developing Erectile Dysfunction. Preventive measure include but are not limited to taking initiatives to managing hypertension, maintaining lipid control, completely omitting cigarette smoking, engaging in adequate physical exercise, as well as reducing alcohol intake.

Treatment and prevention measures can also come in the form of glucose management, and diet changes. Recent clinical studies have shown that better glucose management has “been associated with improvements in sexual function” and reduces the likelihood of developing Erectile Dysfunction. ⁽⁷⁾ According to ISSM and the American Diabetes Association adopting a Mediterranean diet could cut the risk of a man developing erectile dysfunction by 40 percent. ^(12,11) Additionally, the American Association of Diabetes states that the benefits of a Mediterranean diet “on erectile function might be related to an improved lipid and glucose metabolism, increased antioxidant defenses, and increased arginine levels which could raise nitric oxide activity and thus improve erectile function .” ^{(11, 10)}

Supplements can aid in the improvement of Erectile Dysfunction as well. Recent studies also show that “supplementation with amino acids called l-arginine and l-citrulline may help to improve erectile function as these acids are known to increase the body’s production of nitric oxide, which can increase blood flow to the penis.” ⁽⁸⁾ Substituting as well as removing medications that may be linked to Erectile Dysfunction is helpful as well. ^{(2, 9)}

Below are listed lifestyle change measures to consider when treating or preventing Erectile Dysfunction: ⁽⁴⁾

Managing blood sugar levels

A diabetes-friendly well balanced diet assists in controlling blood sugar levels and decreases potential damage which might occur to both blood vessels and nerves.

Limiting the consumption of alcohol

Drinking can often times damage blood vessels which can contribute to erectile dysfunction.

Adopting an active lifestyle

Incorporating regular exercise can assist in controlling the blood sugar levels as well as improve circulation and lower stress.

Quit smoking

Smoking constricts blood vessels and reduces levels of nitric oxide in the blood, which in turn reduces the blood flow towards the penis, therefore contributing to the worsening the condition of erectile dysfunction.

For Diabetic men who have onset Erectile Dysfunction there are several effective therapy options available. Boston Medical Group offers first line pharmacologic therapy options effective for treating Erectile Dysfunction for men who have pre-existing conditions such as Diabetes. The initial steps of Boston Medical Groups consultation includes going over a patient’s background history through a thorough evaluation of their medical conditions, and current health statues in order to distinguish between psychogenic and primary causes. The second step Boston Medical Group initiates includes administering quick, simple non-invasive tests in order to determine severity as well as prognosis. The third step of Boston Medical Group’s comprehensive consultation includes prescribing the best recommended line of therapy for Erectile Dysfunction. Such pharmacologic therapies include oral medications and vasoactive agents in order to thoroughly address the issue at hand.

Sources:

Article source here: The Link between Diabetes, Erectile Dysfunction and Intimacy Issues

Tuesday, January 28, 2020

ED Treatment Specialists in Orlando

In the United States, Boston Medical Group is a network of independent physicians that has dedicated its practices to treating Erectile Dysfunction, Premature Ejaculation and Low Testosterone. The staff of physicians includes Board-Certified Urologists, Family Practitioners, Internists, and other experienced medical professionals. For over 18 years the network has treated over a million men, many of whom previously had unsuccessful experiences with the popular oral medications for ED.

Boston Medical Group
https://www.bostonmedicalgroup.com/locations/detail/orlando/
106 Boston Ave #204, Altamonte Springs, FL 32701, United States
4073620211 / 8777544947
usa@bostonmedicalgroup.com
Opens: Monday - Friday: 8AM - 5PM
Closed: Saturday - Sunday